Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
Location | 177724..178861 | Replicon | plasmid 2 |
Accession | NZ_LR135352 | ||
Organism | Enterococcus faecium isolate E8014 |
Toxin (Protein)
Gene name | zeta | Uniprot ID | P0A4M2 |
Locus tag | EQB45_RS15695 | Protein ID | WP_002332783.1 |
Coordinates | 177724..178587 (-) | Length | 288 a.a. |
Antitoxin (Protein)
Gene name | epsilon | Uniprot ID | Q9AL19 |
Locus tag | EQB45_RS15700 | Protein ID | WP_002326825.1 |
Coordinates | 178589..178861 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQB45_RS15660 | 173410..173982 | - | 573 | WP_002300842.1 | SIS domain-containing protein | - |
EQB45_RS15665 | 173989..174651 | - | 663 | WP_002300841.1 | ribulose-phosphate 3-epimerase | - |
EQB45_RS15670 | 174667..175182 | - | 516 | WP_002300840.1 | YjbQ family protein | - |
EQB45_RS15675 | 175184..175468 | - | 285 | WP_002300838.1 | PTS sugar transporter subunit IIB | - |
EQB45_RS15680 | 175502..176212 | - | 711 | Protein_188 | PTS galactitol transporter subunit IIC | - |
EQB45_RS15685 | 176266..176946 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
EQB45_RS15690 | 177021..177161 | - | 141 | Protein_190 | IS6 family transposase | - |
EQB45_RS15695 | 177724..178587 | - | 864 | WP_002332783.1 | toxin zeta | Toxin |
EQB45_RS15700 | 178589..178861 | - | 273 | WP_002326825.1 | antitoxin | Antitoxin |
EQB45_RS15705 | 178879..179088 | - | 210 | WP_000527318.1 | peptide-binding protein | - |
EQB45_RS15710 | 179186..180082 | - | 897 | WP_002326827.1 | ParA family protein | - |
EQB45_RS15720 | 181604..181864 | - | 261 | Protein_196 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
EQB45_RS15730 | 182034..182771 | - | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
EQB45_RS16710 | 182896..182994 | - | 99 | WP_176698583.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | erm(B) / aac(6')-aph(2'') | - | 1..238961 | 238961 | |
- | inside | IScluster/Tn | erm(B) / aac(6')-aph(2'') | - | 176266..190347 | 14081 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32675.27 Da Isoelectric Point: 7.3939
>T288158 WP_002332783.1 NZ_LR135352:c178587-177724 [Enterococcus faecium]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKYVTPYSNRMTEAIISRLRDKGYNLVIEGTGRTTDVPIQTATMLQAKDYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKYVTPYSNRMTEAIISRLRDKGYNLVIEGTGRTTDVPIQTATMLQAKDYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI
Download Length: 864 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | P0A4M2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AF93 |