Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 8150..8669 Replicon plasmid 4
Accession NZ_LR135334
Organism Enterococcus faecium isolate E7471

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag EQB74_RS16390 Protein ID WP_000588503.1
Coordinates 8412..8669 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag EQB74_RS16385 Protein ID WP_000388479.1
Coordinates 8150..8419 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB74_RS16350 3657..4556 - 900 WP_010708503.1 aminoglycoside O-phosphotransferase APH(2'')-IIa -
EQB74_RS16355 4625..4903 - 279 WP_010708504.1 hypothetical protein -
EQB74_RS16360 5287..6057 - 771 Protein_8 DUF4368 domain-containing protein -
EQB74_RS16365 6057..6737 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EQB74_RS16370 6764..7459 + 696 WP_127843776.1 hypothetical protein -
EQB74_RS16380 7840..8019 + 180 WP_001120991.1 hypothetical protein -
EQB74_RS16385 8150..8419 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB74_RS16390 8412..8669 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
EQB74_RS16395 9128..10132 + 1005 WP_000455809.1 hypothetical protein -
EQB74_RS16400 10297..10911 - 615 WP_001261742.1 recombinase family protein -
EQB74_RS16405 11149..11571 + 423 WP_002303116.1 hypothetical protein -
EQB74_RS16410 11581..11784 + 204 WP_002299573.1 hypothetical protein -
EQB74_RS16415 11995..12579 + 585 WP_002299575.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-Im / aph(2'')-Ib - 1..72466 72466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T288146 WP_000588503.1 NZ_LR135334:8412-8669 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT288146 WP_000388479.1 NZ_LR135334:8150-8419 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References