Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 51694..52228 Replicon plasmid 2
Accession NZ_LR135294
Organism Enterococcus faecium isolate E7237

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag EQB69_RS14105 Protein ID WP_002360769.1
Coordinates 51953..52228 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag EQB69_RS14100 Protein ID WP_002369771.1
Coordinates 51694..51960 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB69_RS14065 47797..48582 + 786 WP_000803546.1 replication-relaxation family protein -
EQB69_RS14070 48588..49076 + 489 WP_002368088.1 hypothetical protein -
EQB69_RS14080 49668..49934 + 267 WP_002368091.1 hypothetical protein -
EQB69_RS14085 49967..50461 + 495 WP_002368092.1 DnaJ domain-containing protein -
EQB69_RS14090 50559..50975 + 417 WP_002368093.1 single-stranded DNA-binding protein -
EQB69_RS14095 50999..51583 + 585 WP_002368095.1 thermonuclease family protein -
EQB69_RS14100 51694..51960 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EQB69_RS14105 51953..52228 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
EQB69_RS14115 53031..53216 + 186 WP_002368099.1 hypothetical protein -
EQB69_RS14120 53238..53384 + 147 WP_002368101.1 DpnD/PcfM family protein -
EQB69_RS14125 53615..54394 + 780 WP_002368102.1 hypothetical protein -
EQB69_RS14130 54394..55653 + 1260 WP_002368103.1 PcfJ domain-containing protein -
EQB69_RS14140 56303..57031 + 729 WP_002368105.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / aac(6')-aph(2'') / aph(3')-III - 1..256017 256017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T288121 WP_002360769.1 NZ_LR135294:51953-52228 [Enterococcus faecium]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT288121 WP_002369771.1 NZ_LR135294:51694-51960 [Enterococcus faecium]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References