Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
Location | 14182..15290 | Replicon | plasmid 3 |
Accession | NZ_LR135260 | ||
Organism | Enterococcus faecium isolate E4457 |
Toxin (Protein)
Gene name | MNTss | Uniprot ID | A0A2H4HI44 |
Locus tag | EQB59_RS14685 | Protein ID | WP_029170889.1 |
Coordinates | 14421..15290 (+) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | Xress | Uniprot ID | - |
Locus tag | EQB59_RS14680 | Protein ID | WP_000205227.1 |
Coordinates | 14182..14406 (+) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQB59_RS15650 | 9771..9941 | + | 171 | WP_000713595.1 | hypothetical protein | - |
EQB59_RS14655 | 9955..10557 | + | 603 | WP_001062586.1 | recombinase family protein | - |
EQB59_RS14660 | 10573..11250 | + | 678 | Protein_14 | DNA topoisomerase | - |
EQB59_RS14665 | 11762..12058 | + | 297 | WP_002360685.1 | hypothetical protein | - |
EQB59_RS14670 | 12059..12475 | + | 417 | WP_000323438.1 | recombinase | - |
EQB59_RS14675 | 12477..14039 | + | 1563 | WP_000136908.1 | recombinase family protein | - |
EQB59_RS14680 | 14182..14406 | + | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin |
EQB59_RS14685 | 14421..15290 | + | 870 | WP_029170889.1 | nucleotidyltransferase domain-containing protein | Toxin |
EQB59_RS14690 | 15271..16005 | + | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
EQB59_RS14695 | 16038..16901 | + | 864 | WP_002294505.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
EQB59_RS14700 | 16945..17472 | + | 528 | WP_002294507.1 | adenine phosphoribosyltransferase | - |
EQB59_RS14705 | 17604..18413 | + | 810 | WP_002294509.1 | ANT(9) family aminoglycoside nucleotidyltransferase Spw | - |
EQB59_RS14710 | 18631..18882 | + | 252 | WP_002294510.1 | hypothetical protein | - |
EQB59_RS14715 | 18933..19391 | - | 459 | WP_002325145.1 | hypothetical protein | - |
EQB59_RS14720 | 19474..20037 | + | 564 | Protein_26 | zinc ribbon domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32820.25 Da Isoelectric Point: 4.9564
>T288107 WP_029170889.1 NZ_LR135260:14421-15290 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIMKDTEHGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAETY
PNALQKSLVNFFMFEAGFSLMFVKANSGTDDKYYIAGHVFRIVSCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIMKDTEHGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAETY
PNALQKSLVNFFMFEAGFSLMFVKANSGTDDKYYIAGHVFRIVSCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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