Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 95967..96538 Replicon plasmid 2
Accession NZ_LR135259
Organism Enterococcus faecium isolate E4457

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EQB59_RS14325 Protein ID WP_002322675.1
Coordinates 96197..96538 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EQB59_RS14320 Protein ID WP_002322676.1
Coordinates 95967..96197 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB59_RS14295 91039..91593 - 555 WP_002295761.1 tyrosine-type recombinase/integrase -
EQB59_RS14300 92336..92896 + 561 WP_002347210.1 hypothetical protein -
EQB59_RS14305 92929..93741 - 813 WP_002322679.1 AAA family ATPase -
EQB59_RS14310 93734..95170 - 1437 WP_002322678.1 DDE-type integrase/transposase/recombinase -
EQB59_RS14315 95142..95735 - 594 WP_002322677.1 recombinase family protein -
EQB59_RS14320 95967..96197 + 231 WP_002322676.1 hypothetical protein Antitoxin
EQB59_RS14325 96197..96538 + 342 WP_002322675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQB59_RS14330 96752..98254 - 1503 WP_002322674.1 xylulokinase -
EQB59_RS14335 98327..99379 - 1053 WP_002323515.1 sugar ABC transporter substrate-binding protein -
EQB59_RS14340 99432..100400 - 969 WP_002322672.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..148571 148571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13232.43 Da        Isoelectric Point: 9.4128

>T288105 WP_002322675.1 NZ_LR135259:96197-96538 [Enterococcus faecium]
MTEEKNYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIRNFPTRYSLPTELDTTGQILISQ
LKSLDFNERKLKKIESLPLQDMAKIDQMIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8551.48 Da        Isoelectric Point: 4.0070

>AT288105 WP_002322676.1 NZ_LR135259:95967-96197 [Enterococcus faecium]
MLITKSRLQGSSVVITLPSDNGKKPSENKEYIVIYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLSPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References