Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
Location | 133774..134882 | Replicon | plasmid 3 |
Accession | NZ_LR135256 | ||
Organism | Enterococcus faecium isolate E7098 |
Toxin (Protein)
Gene name | MNTss | Uniprot ID | A0A0M4MHJ8 |
Locus tag | EQB68_RS15730 | Protein ID | WP_002303392.1 |
Coordinates | 133774..134643 (-) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | Xress | Uniprot ID | B9DSK1 |
Locus tag | EQB68_RS15735 | Protein ID | WP_002303393.1 |
Coordinates | 134658..134882 (-) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQB68_RS15700 | 129070..129321 | - | 252 | Protein_155 | GNAT family N-acetyltransferase | - |
EQB68_RS15705 | 129566..130861 | + | 1296 | WP_002297218.1 | ISL3-like element ISEfa11 family transposase | - |
EQB68_RS15710 | 130962..131870 | + | 909 | WP_002324522.1 | IS982-like element ISEfm1 family transposase | - |
EQB68_RS15715 | 131873..132121 | - | 249 | WP_002347175.1 | hypothetical protein | - |
EQB68_RS15720 | 132118..133026 | - | 909 | WP_001255866.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
EQB68_RS15725 | 133059..133793 | - | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
EQB68_RS15730 | 133774..134643 | - | 870 | WP_002303392.1 | nucleotidyltransferase domain-containing protein | Toxin |
EQB68_RS15735 | 134658..134882 | - | 225 | WP_002303393.1 | helix-turn-helix transcriptional regulator | Antitoxin |
EQB68_RS15740 | 135025..135846 | - | 822 | Protein_163 | recombinase zinc beta ribbon domain-containing protein | - |
EQB68_RS15745 | 136534..137337 | - | 804 | WP_002294514.1 | lincosamide nucleotidyltransferase Lnu(B) | - |
EQB68_RS15750 | 137391..138326 | - | 936 | Protein_165 | ABC-F type ribosomal protection protein Lsa(E) | - |
EQB68_RS15755 | 138381..139061 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | VanHAX / erm(B) / aph(3')-III / ant(6)-Ia / lnu(B) / tet(L) | - | 1..155151 | 155151 | |
- | inside | IScluster/Tn | erm(B) / aph(3')-III / ant(6)-Ia / lnu(B) / tet(L) | - | 98927..148173 | 49246 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32807.38 Da Isoelectric Point: 4.7269
>T288101 WP_002303392.1 NZ_LR135256:c134643-133774 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M4MHJ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1M5SHM7 |