Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 167273..167844 Replicon plasmid 2
Accession NZ_LR135244
Organism Enterococcus faecium isolate E6988

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EQB64_RS14990 Protein ID WP_002322675.1
Coordinates 167503..167844 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EQB64_RS14985 Protein ID WP_002322676.1
Coordinates 167273..167503 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB64_RS14960 162345..162899 - 555 WP_002303574.1 tyrosine-type recombinase/integrase -
EQB64_RS14965 163642..164202 + 561 WP_002347210.1 hypothetical protein -
EQB64_RS14970 164235..165047 - 813 WP_002322679.1 AAA family ATPase -
EQB64_RS14975 165040..166476 - 1437 WP_002322678.1 DDE-type integrase/transposase/recombinase -
EQB64_RS14980 166448..167041 - 594 WP_002322677.1 recombinase family protein -
EQB64_RS14985 167273..167503 + 231 WP_002322676.1 hypothetical protein Antitoxin
EQB64_RS14990 167503..167844 + 342 WP_002322675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQB64_RS14995 168058..169560 - 1503 WP_002322674.1 xylulokinase -
EQB64_RS15000 169633..170685 - 1053 WP_002323515.1 sugar ABC transporter substrate-binding protein -
EQB64_RS15005 170738..171706 - 969 WP_002322672.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') / aph(2'')-Ia - 1..216239 216239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13232.43 Da        Isoelectric Point: 9.4128

>T288093 WP_002322675.1 NZ_LR135244:167503-167844 [Enterococcus faecium]
MTEEKNYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIRNFPTRYSLPTELDTTGQILISQ
LKSLDFNERKLKKIESLPLQDMAKIDQMIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8551.48 Da        Isoelectric Point: 4.0070

>AT288093 WP_002322676.1 NZ_LR135244:167273-167503 [Enterococcus faecium]
MLITKSRLQGSSVVITLPSDNGKKPSENKEYIVIYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLSPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References