Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
Location | 20829..21966 | Replicon | plasmid 5 |
Accession | NZ_LR135239 | ||
Organism | Enterococcus faecium isolate E7067 |
Toxin (Protein)
Gene name | zeta | Uniprot ID | Q54944 |
Locus tag | EQB63_RS15865 | Protein ID | WP_001284311.1 |
Coordinates | 20829..21692 (-) | Length | 288 a.a. |
Antitoxin (Protein)
Gene name | epsilon | Uniprot ID | R2XCR7 |
Locus tag | EQB63_RS15870 | Protein ID | WP_000301765.1 |
Coordinates | 21694..21966 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQB63_RS15835 | 16401..17696 | - | 1296 | WP_002297218.1 | ISL3-like element ISEfa11 family transposase | - |
EQB63_RS15840 | 17941..18192 | + | 252 | Protein_21 | GNAT family N-acetyltransferase | - |
EQB63_RS15845 | 18285..19079 | + | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
EQB63_RS15850 | 19489..19572 | + | 84 | Protein_23 | peptide-binding protein | - |
EQB63_RS15855 | 19621..19704 | + | 84 | WP_031929417.1 | 23S rRNA methyltransferase attenuator leader peptide ErmL | - |
EQB63_RS15860 | 19829..20566 | + | 738 | WP_001038796.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
EQB63_RS15865 | 20829..21692 | - | 864 | WP_001284311.1 | toxin zeta | Toxin |
EQB63_RS15870 | 21694..21966 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
EQB63_RS15875 | 21983..22192 | - | 210 | WP_000527318.1 | peptide-binding protein | - |
EQB63_RS15880 | 22290..22541 | - | 252 | Protein_29 | chromosome partitioning protein ParA | - |
EQB63_RS15885 | 22561..23520 | + | 960 | WP_002287225.1 | IS30 family transposase | - |
EQB63_RS15890 | 23544..23840 | - | 297 | WP_000053907.1 | replication control protein PrgN | - |
EQB63_RS15895 | 23975..25468 | - | 1494 | WP_000947691.1 | primase C-terminal domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | VanHAX / lnu(B) / ant(6)-Ia / aph(3')-III / erm(B) | - | 1..51960 | 51960 | |
- | inside | IScluster/Tn | VanHAX / lnu(B) / ant(6)-Ia / aph(3')-III / erm(B) | - | 4313..48735 | 44422 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32404.02 Da Isoelectric Point: 6.9964
>T288089 WP_001284311.1 NZ_LR135239:c21692-20829 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI
Download Length: 864 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 1GVN | |
PDB | 3Q8X |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F0A3 |