288067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 2690..3314 Replicon plasmid 4
Accession NZ_LR135206
Organism Enterococcus faecium isolate E7171

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag EQB62_RS16055 Protein ID WP_127822567.1
Coordinates 2690..3040 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag EQB62_RS16060 Protein ID WP_000301765.1
Coordinates 3042..3314 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB62_RS16040 1..683 - 683 WP_127824146.1 D-alanine--(R)-lactate ligase VanA -
EQB62_RS16045 676..1644 - 969 WP_001059542.1 D-lactate dehydrogenase VanH-A -
EQB62_RS16050 1976..2656 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EQB62_RS16055 2690..3040 - 351 WP_127822567.1 zeta toxin family protein Toxin
EQB62_RS16060 3042..3314 - 273 WP_000301765.1 antitoxin Antitoxin
EQB62_RS16065 3331..3540 - 210 WP_000527318.1 peptide-binding protein -
EQB62_RS16070 3638..3889 - 252 Protein_6 chromosome partitioning protein ParA -
EQB62_RS16075 3909..4868 + 960 WP_002287225.1 IS30 family transposase -
EQB62_RS16080 4892..5188 - 297 WP_000053907.1 replication control protein PrgN -
EQB62_RS16085 5323..6816 - 1494 WP_000947691.1 primase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38582 38582
- inside IScluster/Tn - - 1976..29152 27176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-112)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12959.56 Da        Isoelectric Point: 5.1679

>T288067 WP_127822567.1 NZ_LR135206:c3040-2690 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGGSVAKF

Download         Length: 351 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT288067 WP_000301765.1 NZ_LR135206:c3314-3042 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References