Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 45293..45900 | Replicon | plasmid 3 |
Accession | NZ_LR135199 | ||
Organism | Enterococcus faecium isolate E6055 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | E3USU0 |
Locus tag | EQB61_RS15390 | Protein ID | WP_002321032.1 |
Coordinates | 45550..45900 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A829F3C0 |
Locus tag | EQB61_RS15385 | Protein ID | WP_002287514.1 |
Coordinates | 45293..45556 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQB61_RS15345 | 40604..40864 | + | 261 | WP_002296240.1 | hypothetical protein | - |
EQB61_RS15350 | 41309..41515 | + | 207 | WP_002325537.1 | hypothetical protein | - |
EQB61_RS15355 | 41563..41766 | + | 204 | WP_110300627.1 | hypothetical protein | - |
EQB61_RS15360 | 41782..42219 | + | 438 | WP_002332738.1 | hypothetical protein | - |
EQB61_RS15365 | 42212..42919 | + | 708 | WP_002332739.1 | hypothetical protein | - |
EQB61_RS15375 | 43299..43478 | + | 180 | WP_002305761.1 | hypothetical protein | - |
EQB61_RS15380 | 43812..44999 | - | 1188 | WP_002296840.1 | IS256-like element IS16 family transposase | - |
EQB61_RS15385 | 45293..45556 | + | 264 | WP_002287514.1 | hypothetical protein | Antitoxin |
EQB61_RS15390 | 45550..45900 | + | 351 | WP_002321032.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
EQB61_RS15395 | 45924..46538 | - | 615 | WP_002318230.1 | recombinase family protein | - |
EQB61_RS15400 | 46852..47274 | + | 423 | WP_002288787.1 | hypothetical protein | - |
EQB61_RS15405 | 47284..47487 | + | 204 | WP_002299573.1 | hypothetical protein | - |
EQB61_RS15410 | 47698..48282 | + | 585 | WP_002299575.1 | recombinase family protein | - |
EQB61_RS15415 | 48653..49978 | + | 1326 | WP_127836273.1 | Y-family DNA polymerase | - |
EQB61_RS15420 | 49971..50321 | + | 351 | WP_002300100.1 | hypothetical protein | - |
EQB61_RS15425 | 50318..50497 | + | 180 | WP_002300101.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..54628 | 54628 | |
- | flank | IS/Tn | - | - | 43812..44999 | 1187 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13255.28 Da Isoelectric Point: 8.0280
>T288061 WP_002321032.1 NZ_LR135199:45550-45900 [Enterococcus faecium]
MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK
MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK
Download Length: 351 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F5H8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F3C0 |