Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 92711..93282 Replicon plasmid 2
Accession NZ_LR135192
Organism Enterococcus faecium isolate E4438

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL354_RS14535 Protein ID WP_002322675.1
Coordinates 92941..93282 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL354_RS14530 Protein ID WP_002322676.1
Coordinates 92711..92941 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL354_RS14505 87783..88337 - 555 WP_002295761.1 tyrosine-type recombinase/integrase -
EL354_RS14510 89080..89640 + 561 WP_002347210.1 hypothetical protein -
EL354_RS14515 89673..90485 - 813 WP_002322679.1 AAA family ATPase -
EL354_RS14520 90478..91914 - 1437 WP_002322678.1 DDE-type integrase/transposase/recombinase -
EL354_RS14525 91886..92479 - 594 WP_002322677.1 recombinase family protein -
EL354_RS14530 92711..92941 + 231 WP_002322676.1 hypothetical protein Antitoxin
EL354_RS14535 92941..93282 + 342 WP_002322675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL354_RS14540 93496..94998 - 1503 WP_002322674.1 xylulokinase -
EL354_RS14545 95071..96123 - 1053 WP_002323515.1 sugar ABC transporter substrate-binding protein -
EL354_RS14550 96176..97144 - 969 WP_002322672.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..145361 145361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13232.43 Da        Isoelectric Point: 9.4128

>T288056 WP_002322675.1 NZ_LR135192:92941-93282 [Enterococcus faecium]
MTEEKNYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIRNFPTRYSLPTELDTTGQILISQ
LKSLDFNERKLKKIESLPLQDMAKIDQMIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8551.48 Da        Isoelectric Point: 4.0070

>AT288056 WP_002322676.1 NZ_LR135192:92711-92941 [Enterococcus faecium]
MLITKSRLQGSSVVITLPSDNGKKPSENKEYIVIYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLSPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References