288053

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 18183..19291 Replicon plasmid 3
Accession NZ_LR135183
Organism Enterococcus faecium isolate E1774

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag EL353_RS14825 Protein ID WP_000233000.1
Coordinates 18183..19052 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag EL353_RS14830 Protein ID WP_000205227.1
Coordinates 19067..19291 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL353_RS14790 13436..13999 - 564 Protein_13 zinc ribbon domain-containing protein -
EL353_RS14795 14082..14540 + 459 WP_002325145.1 hypothetical protein -
EL353_RS14800 14591..14842 - 252 WP_002294510.1 hypothetical protein -
EL353_RS14805 15060..15869 - 810 WP_002294509.1 ANT(9) family aminoglycoside nucleotidyltransferase Spw -
EL353_RS14810 16001..16528 - 528 WP_002294507.1 adenine phosphoribosyltransferase -
EL353_RS14815 16572..17435 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
EL353_RS14820 17468..18202 - 735 WP_010733554.1 class I SAM-dependent methyltransferase -
EL353_RS14825 18183..19052 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
EL353_RS14830 19067..19291 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
EL353_RS14835 19434..20996 - 1563 WP_000136908.1 recombinase family protein -
EL353_RS14840 20998..21414 - 417 WP_000323438.1 recombinase -
EL353_RS14845 21415..21711 - 297 WP_002360685.1 hypothetical protein -
EL353_RS14850 22223..22900 - 678 Protein_25 DNA topoisomerase -
EL353_RS14855 22916..23518 - 603 WP_001062586.1 recombinase family protein -
EL353_RS15120 23532..23702 - 171 WP_000713595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T288053 WP_000233000.1 NZ_LR135183:c19052-18183 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT288053 WP_000205227.1 NZ_LR135183:c19291-19067 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References