Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 51685..52822 Replicon plasmid 2
Accession NZ_LR135180
Organism Enterococcus faecium isolate E0595

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag EL352_RS12780 Protein ID WP_084679662.1
Coordinates 51959..52822 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID -
Locus tag EL352_RS12775 Protein ID WP_126347911.1
Coordinates 51685..51957 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL352_RS12760 48706..50382 + 1677 WP_126347913.1 type IA DNA topoisomerase -
EL352_RS12765 50464..51360 + 897 WP_002333001.1 ParA family protein -
EL352_RS12770 51458..51667 + 210 WP_000527318.1 peptide-binding protein -
EL352_RS12775 51685..51957 + 273 WP_126347911.1 antitoxin Antitoxin
EL352_RS12780 51959..52822 + 864 WP_084679662.1 zeta toxin family protein Toxin
EL352_RS12785 52944..53441 + 498 WP_096710545.1 molecular chaperone DnaJ -
EL352_RS12790 53526..54122 - 597 WP_002326773.1 TetR/AcrR family transcriptional regulator -
EL352_RS12795 54434..55315 + 882 WP_074626908.1 ABC transporter ATP-binding protein -
EL352_RS12800 55339..56952 + 1614 WP_126347912.1 tetronasin resistance protein -
EL352_RS12805 57024..57536 - 513 Protein_59 IS30 family transposase -
EL352_RS13455 57594..57712 + 119 Protein_60 zeta toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / VanHAX - 1..139885 139885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32437.91 Da        Isoelectric Point: 6.1573

>T288049 WP_084679662.1 NZ_LR135180:51959-52822 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPNNLETLQKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10735.36 Da        Isoelectric Point: 8.3744

>AT288049 WP_126347911.1 NZ_LR135180:51685-51957 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLKQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References