Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 473236..473807 Replicon chromosome
Accession NZ_LR135179
Organism Enterococcus faecium isolate E0595

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL352_RS02440 Protein ID WP_002328559.1
Coordinates 473466..473807 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag EL352_RS02435 Protein ID WP_002323011.1
Coordinates 473236..473466 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL352_RS02390 468354..469682 + 1329 WP_002327663.1 FAD-containing oxidoreductase -
EL352_RS02395 469704..470330 + 627 WP_002286816.1 cysteine hydrolase -
EL352_RS02400 470513..471094 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
EL352_RS02420 471826..472401 + 576 WP_002327664.1 SOS response-associated peptidase family protein -
EL352_RS02425 472602..472976 - 375 WP_158225605.1 hypothetical protein -
EL352_RS02435 473236..473466 + 231 WP_002323011.1 hypothetical protein Antitoxin
EL352_RS02440 473466..473807 + 342 WP_002328559.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL352_RS02445 474626..475788 + 1163 WP_086956687.1 IS3 family transposase -
EL352_RS02455 475919..477103 + 1185 Protein_451 hypothetical protein -
EL352_RS02460 477103..478416 + 1314 WP_002328556.1 LPXTG-protein cell wall anchor protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13278.70 Da        Isoelectric Point: 10.1461

>T288048 WP_002328559.1 NZ_LR135179:473466-473807 [Enterococcus faecium]
VSGERIYIPKKGDIVWIYFDPSLGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT288048 WP_002323011.1 NZ_LR135179:473236-473466 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References