288042

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 429937..430508 Replicon chromosome
Accession NZ_LR135170
Organism Enterococcus faecium isolate E4227

Toxin (Protein)


Gene name mazF Uniprot ID A0A828ZXV4
Locus tag EL345_RS02240 Protein ID WP_002302307.1
Coordinates 430167..430508 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag EL345_RS02235 Protein ID WP_002323011.1
Coordinates 429937..430167 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL345_RS02195 425414..426745 + 1332 WP_002346495.1 FAD-dependent oxidoreductase -
EL345_RS02200 426767..427393 + 627 WP_002346494.1 cysteine hydrolase -
EL345_RS02205 427586..428167 + 582 WP_002300332.1 TetR/AcrR family transcriptional regulator -
EL345_RS02220 428531..429106 + 576 WP_002302305.1 SOS response-associated peptidase family protein -
EL345_RS02225 429311..429649 - 339 WP_002286804.1 hypothetical protein -
EL345_RS02235 429937..430167 + 231 WP_002323011.1 hypothetical protein Antitoxin
EL345_RS02240 430167..430508 + 342 WP_002302307.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL345_RS02250 432974..435478 + 2505 WP_002323736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13288.65 Da        Isoelectric Point: 9.9044

>T288042 WP_002302307.1 NZ_LR135170:430167-430508 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT288042 WP_002323011.1 NZ_LR135170:429937-430167 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXV4

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References