Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 190591..191120 Replicon chromosome
Accession NZ_LR135170
Organism Enterococcus faecium isolate E4227

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag EL345_RS01015 Protein ID WP_002294198.1
Coordinates 190854..191120 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1S8JTG2
Locus tag EL345_RS01010 Protein ID WP_002317080.1
Coordinates 190591..190854 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL345_RS00995 187967..189790 + 1824 WP_002294202.1 APC family permease -
EL345_RS01000 189932..190116 - 185 Protein_186 transcriptional regulator -
EL345_RS01010 190591..190854 + 264 WP_002317080.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL345_RS01015 190854..191120 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
EL345_RS01020 191321..191809 + 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
EL345_RS01025 192351..193022 - 672 WP_002319469.1 ABC transporter permease -
EL345_RS01030 193019..193936 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
EL345_RS01035 193933..194574 - 642 WP_002293405.1 ABC transporter permease -
EL345_RS01040 194578..195753 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T288041 WP_002294198.1 NZ_LR135170:190854-191120 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10015.04 Da        Isoelectric Point: 4.1844

>AT288041 WP_002317080.1 NZ_LR135170:190591-190854 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8JTG2

References