Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 488357..489465 Replicon chromosome
Accession NZ_LR135169
Organism Enterococcus faecium isolate E2079

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag EL351_RS02520 Protein ID WP_000233000.1
Coordinates 488596..489465 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag EL351_RS02515 Protein ID WP_000205227.1
Coordinates 488357..488581 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL351_RS02475 483456..484031 + 576 WP_002327664.1 SOS response-associated peptidase family protein -
EL351_RS02480 484232..484606 - 375 WP_158225605.1 hypothetical protein -
EL351_RS02490 484866..485096 + 231 WP_002323011.1 hypothetical protein -
EL351_RS02495 485096..485440 + 345 WP_126305268.1 type II toxin-antitoxin system PemK/MazF family toxin -
EL351_RS13105 485736..485900 + 165 Protein_460 DNA recombinase -
EL351_RS02500 485937..486233 + 297 WP_002360685.1 hypothetical protein -
EL351_RS02505 486234..486650 + 417 WP_000323438.1 recombinase -
EL351_RS02510 486670..488214 + 1545 WP_002390960.1 recombinase family protein -
EL351_RS02515 488357..488581 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
EL351_RS02520 488596..489465 + 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
EL351_RS02525 489446..490180 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
EL351_RS02530 490213..491076 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
EL351_RS02535 491120..491647 + 528 WP_002294507.1 adenine phosphoribosyltransferase -
EL351_RS02540 491875..493194 + 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T288040 WP_000233000.1 NZ_LR135169:488596-489465 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT288040 WP_000205227.1 NZ_LR135169:488357-488581 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References