Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 163199..163838 Replicon chromosome
Accession NZ_LR135168
Organism Mycobacterium ulcerans strain SGL03 isolate ITM032481

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag EQB88_RS00825 Protein ID WP_011738541.1
Coordinates 163199..163645 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag EQB88_RS00830 Protein ID WP_011738542.1
Coordinates 163650..163838 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB88_RS00800 158372..159892 + 1521 WP_011738537.1 carotenoid oxygenase family protein -
EQB88_RS00805 159909..160382 + 474 WP_071498317.1 VOC family protein -
EQB88_RS00810 160388..160822 - 435 WP_011738539.1 hypothetical protein -
EQB88_RS00815 160893..161666 - 774 WP_011738540.1 VOC family protein -
EQB88_RS00820 161832..163087 + 1256 Protein_158 hypothetical protein -
EQB88_RS00825 163199..163645 - 447 WP_011738541.1 SRPBCC family protein Toxin
EQB88_RS00830 163650..163838 - 189 WP_011738542.1 antitoxin Antitoxin
EQB88_RS00835 163940..164562 - 623 Protein_161 hypothetical protein -
EQB88_RS00840 164725..165225 - 501 Protein_162 hypothetical protein -
EQB88_RS00845 165224..166558 + 1335 WP_011738543.1 IS256 family transposase -
EQB88_RS00850 166615..166848 + 234 Protein_164 IS256 family transposase -
EQB88_RS00855 166925..167912 - 988 Protein_165 ISAs1 family transposase -
EQB88_RS00860 167912..168167 - 256 Protein_166 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15808.38 Da        Isoelectric Point: 7.3597

>T288037 WP_011738541.1 NZ_LR135168:c163645-163199 [Mycobacterium ulcerans]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVCYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSIVSFDVHLGGPALFGPIGMVVAAALRSDINASLRNFVTVFAPPAAG

Download         Length: 447 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT288037 WP_011738542.1 NZ_LR135168:c163838-163650 [Mycobacterium ulcerans]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References