Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 1539567..1540050 Replicon chromosome
Accession NZ_LR134538
Organism Corynebacterium diphtheriae strain NCTC3529

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EL331_RS07230 Protein ID WP_014317255.1
Coordinates 1539567..1539836 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag EL331_RS07235 Protein ID WP_014317256.1
Coordinates 1539817..1540050 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL331_RS07210 1536311..1536910 - 600 WP_016829867.1 RloB family protein -
EL331_RS07215 1536937..1538268 - 1332 WP_014317252.1 ATP-binding protein -
EL331_RS07225 1538850..1539224 + 375 Protein_1376 transposase -
EL331_RS07230 1539567..1539836 - 270 WP_014317255.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL331_RS07235 1539817..1540050 - 234 WP_014317256.1 ribbon-helix-helix protein, CopG family Antitoxin
EL331_RS07240 1540362..1541356 + 995 Protein_1379 IS3 family transposase -
EL331_RS07250 1542198..1542473 + 276 WP_016829857.1 hypothetical protein -
EL331_RS07255 1542598..1543977 - 1380 WP_072574736.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1530911..1561748 30837
- flank IS/Tn - - 1544202..1545350 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10217.79 Da        Isoelectric Point: 10.6133

>T288035 WP_014317255.1 NZ_LR134538:c1539836-1539567 [Corynebacterium diphtheriae]
VTSWAIEFSPRAAKELRKLGRPVQKHIVAYLREISTLPNPQMRGKALTGNWAGFWRWRVGDYRLVAAIEDDRVVVVVVSI
GHRSQVYED

Download         Length: 270 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8917.92 Da        Isoelectric Point: 4.4766

>AT288035 WP_014317256.1 NZ_LR134538:c1540050-1539817 [Corynebacterium diphtheriae]
MSNPVISLRIGASEKERLDELSRRTGRSGSFYIREALEKHLDELEYVYGVRSEYEAIRRGELETISLDEVERDLLGD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References