Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1953056..1953565 Replicon chromosome
Accession NZ_LR134536
Organism Staphylococcus epidermidis strain NCTC13924

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag EL299_RS09735 Protein ID WP_001829980.1
Coordinates 1953056..1953265 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag EL299_RS09740 Protein ID WP_001829893.1
Coordinates 1953272..1953565 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL299_RS09715 1948634..1949989 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
EL299_RS09720 1950001..1951074 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
EL299_RS09725 1951465..1952676 + 1212 WP_001829910.1 rod shape-determining protein RodA -
EL299_RS09730 1952776..1952913 - 138 WP_001829949.1 hypothetical protein -
EL299_RS09735 1953056..1953265 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
EL299_RS09740 1953272..1953565 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL299_RS09745 1953739..1955223 + 1485 WP_002457116.1 cardiolipin synthase -
EL299_RS09750 1955405..1956058 + 654 WP_001829983.1 HD domain-containing protein -
EL299_RS09755 1956164..1957036 - 873 WP_002458703.1 membrane protein insertase YidC -
EL299_RS09760 1957125..1957763 - 639 WP_002505076.1 thiamine phosphate synthase -
EL299_RS09765 1957769..1958557 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T288034 WP_001829980.1 NZ_LR134536:c1953265-1953056 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT288034 WP_001829893.1 NZ_LR134536:c1953565-1953272 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References