Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1941853..1942382 Replicon chromosome
Accession NZ_LR134536
Organism Staphylococcus epidermidis strain NCTC13924

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag EL299_RS09675 Protein ID WP_001829891.1
Coordinates 1941853..1942215 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag EL299_RS09680 Protein ID WP_001829931.1
Coordinates 1942212..1942382 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL299_RS09655 1938854..1939624 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
EL299_RS09660 1939599..1940078 - 480 WP_001829903.1 anti-sigma B factor RsbW -
EL299_RS09665 1940080..1940406 - 327 WP_001829952.1 anti-sigma factor antagonist -
EL299_RS09670 1940506..1941507 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
EL299_RS09675 1941853..1942215 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL299_RS09680 1942212..1942382 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EL299_RS09685 1942469..1943617 - 1149 WP_002468951.1 alanine racemase -
EL299_RS09690 1943683..1944036 - 354 WP_001829915.1 holo-ACP synthase -
EL299_RS09695 1944084..1944593 - 510 WP_001829888.1 PH domain-containing protein -
EL299_RS09700 1944580..1946085 - 1506 WP_001829976.1 PH domain-containing protein -
EL299_RS09705 1946078..1946557 - 480 WP_001829909.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T288033 WP_001829891.1 NZ_LR134536:c1942215-1941853 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT288033 WP_001829931.1 NZ_LR134536:c1942382-1942212 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References