Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1139988..1140616 Replicon chromosome
Accession NZ_LR134533
Organism Neisseria weaveri strain NCTC12742

Toxin (Protein)


Gene name vapC Uniprot ID A0A3S5B4U2
Locus tag EL309_RS05610 Protein ID WP_040669919.1
Coordinates 1140215..1140616 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3S4ZDA2
Locus tag EL309_RS05605 Protein ID WP_004284447.1
Coordinates 1139988..1140212 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL309_RS05580 1135474..1135938 - 465 WP_004284441.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL309_RS10730 1136004..1136717 - 714 WP_193777301.1 ComF family protein -
EL309_RS05590 1136716..1137459 + 744 WP_004284444.1 pimeloyl-ACP methyl ester esterase BioH -
EL309_RS05595 1137535..1138323 + 789 WP_004284445.1 methyltransferase domain-containing protein -
EL309_RS05600 1138475..1139842 + 1368 WP_004284446.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EL309_RS05605 1139988..1140212 + 225 WP_004284447.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL309_RS05610 1140215..1140616 + 402 WP_040669919.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL309_RS05615 1140972..1142141 + 1170 WP_004284449.1 benzoate/H(+) symporter BenE family transporter -
EL309_RS05620 1142392..1143813 + 1422 WP_004284450.1 alanine:cation symporter family protein -
EL309_RS05625 1143915..1144715 - 801 WP_004284451.1 cytochrome c biogenesis protein CcsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14837.17 Da        Isoelectric Point: 7.9466

>T288024 WP_040669919.1 NZ_LR134533:1140215-1140616 [Neisseria weaveri]
MLRYMLDINICIYTIKNNPAAVREKFQQHQHHMCISSIVLTELLYGAEKSSNPAKSLALIEGMAARLEVLNFDETAAAHA
AEIRADLARKGTPIGHYDVLIAGHARSRGLILVSNNLREFERVAGLRLENWAV

Download         Length: 402 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8436.55 Da        Isoelectric Point: 4.6721

>AT288024 WP_004284447.1 NZ_LR134533:1139988-1140212 [Neisseria weaveri]
MAQATLFKSNQTQAVRLPKAVAFPDDVKKVEVVVLGKSRLLTPSENLWDDWFAQLPQADFPDREPSFQAERESF

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5B4U2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4ZDA2

References