Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1293782..1294335 Replicon chromosome
Accession NZ_LR134531
Organism Pragia fontium strain NCTC12284

Toxin (Protein)


Gene name ccdB Uniprot ID A0A379DPD7
Locus tag EL341_RS05450 Protein ID WP_074820802.1
Coordinates 1294027..1294335 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag EL341_RS05445 Protein ID WP_074821490.1
Coordinates 1293782..1294024 (+) Length 81 a.a.

Genomic Context

EL341_RS05430EL341_RS05435EL341_RS05440EL341_RS05445EL341_RS05450EL341_RS05455EL341_RS05460EL341_RS05465EL341_RS05470
Location: 1289326..1291134 (1809 bp)
Type: Others
Protein ID: WP_126467215.1
Location: 1291134..1292843 (1710 bp)
Type: Others
Protein ID: WP_047780462.1
Location: 1292853..1293587 (735 bp)
Type: Others
Protein ID: WP_047780463.1
Location: 1293782..1294024 (243 bp)
Type: Antitoxin
Protein ID: WP_074821490.1
Location: 1294027..1294335 (309 bp)
Type: Toxin
Protein ID: WP_074820802.1
Location: 1294722..1296152 (1431 bp)
Type: Others
Protein ID: WP_074820806.1
Location: 1296185..1297093 (909 bp)
Type: Others
Protein ID: WP_047782550.1
Location: 1297134..1298561 (1428 bp)
Type: Others
Protein ID: WP_047782551.1
Location: 1298568..1299164 (597 bp)
Type: Others
Protein ID: WP_074820808.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL341_RS054301289326..1291134+1809WP_126467215.1NADPH-dependent assimilatory sulfite reductase flavoprotein subunit-
EL341_RS054351291134..1292843+1710WP_047780462.1assimilatory sulfite reductase (NADPH) hemoprotein subunit-
EL341_RS054401292853..1293587+735WP_047780463.1phosphoadenylyl-sulfate reductase-
EL341_RS054451293782..1294024+243WP_074821490.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
EL341_RS054501294027..1294335+309WP_074820802.1CcdB family proteinToxin
EL341_RS054551294722..1296152+1431WP_074820806.1siroheme synthase CysG-
EL341_RS054601296185..1297093+909WP_047782550.1sulfate adenylyltransferase subunit CysD-
EL341_RS054651297134..1298561+1428WP_047782551.1sulfate adenylyltransferase subunit CysN-
EL341_RS054701298568..1299164+597WP_074820808.1adenylyl-sulfate kinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(10-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11703.48 Da        Isoelectric Point: 6.5972

>T288021 WP_074820802.1 NZ_LR134531:1294027-1294335 [Pragia fontium]
MQYAVYRHAGNSKDYPYLLNIQSDLIGALNTRLVIPLFPLNRFTGNRPQHLCPVLHIENSDFLVMTHEMASVRQTMLGEV
VCHVDHHRDEIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9141.30 Da        Isoelectric Point: 6.9764

>AT288021 WP_074821490.1 NZ_LR134531:1293782-1294024 [Pragia fontium]
MSVTHAKTTKKTVSVTLDPDLYQRARDMGINLSALLTQAVEQQLQAASRAQWQRDNQQAMEELNRITERCGLLSDEYRAF

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A379DPD7

Antitoxin

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Source
ID
Structure
No matching records found

References