Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1293782..1294335 Replicon chromosome
Accession NZ_LR134531
Organism Pragia fontium strain NCTC12284

Toxin (Protein)


Gene name ccdB Uniprot ID A0A379DPD7
Locus tag EL341_RS05450 Protein ID WP_074820802.1
Coordinates 1294027..1294335 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag EL341_RS05445 Protein ID WP_074821490.1
Coordinates 1293782..1294024 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL341_RS05430 1289326..1291134 + 1809 WP_126467215.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
EL341_RS05435 1291134..1292843 + 1710 WP_047780462.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
EL341_RS05440 1292853..1293587 + 735 WP_047780463.1 phosphoadenylyl-sulfate reductase -
EL341_RS05445 1293782..1294024 + 243 WP_074821490.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EL341_RS05450 1294027..1294335 + 309 WP_074820802.1 CcdB family protein Toxin
EL341_RS05455 1294722..1296152 + 1431 WP_074820806.1 siroheme synthase CysG -
EL341_RS05460 1296185..1297093 + 909 WP_047782550.1 sulfate adenylyltransferase subunit CysD -
EL341_RS05465 1297134..1298561 + 1428 WP_047782551.1 sulfate adenylyltransferase subunit CysN -
EL341_RS05470 1298568..1299164 + 597 WP_074820808.1 adenylyl-sulfate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(10-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11703.48 Da        Isoelectric Point: 6.5972

>T288021 WP_074820802.1 NZ_LR134531:1294027-1294335 [Pragia fontium]
MQYAVYRHAGNSKDYPYLLNIQSDLIGALNTRLVIPLFPLNRFTGNRPQHLCPVLHIENSDFLVMTHEMASVRQTMLGEV
VCHVDHHRDEIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9141.30 Da        Isoelectric Point: 6.9764

>AT288021 WP_074821490.1 NZ_LR134531:1293782-1294024 [Pragia fontium]
MSVTHAKTTKKTVSVTLDPDLYQRARDMGINLSALLTQAVEQQLQAASRAQWQRDNQQAMEELNRITERCGLLSDEYRAF

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379DPD7

Antitoxin

Source ID Structure

References