Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 988118..988691 Replicon chromosome
Accession NZ_LR134527
Organism Bartonella elizabethae strain NCTC12898

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EL285_RS04315 Protein ID WP_026500960.1
Coordinates 988118..988426 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID J1A1Y8
Locus tag EL285_RS04320 Protein ID WP_005775091.1
Coordinates 988407..988691 (+) Length 95 a.a.

Genomic Context

EL285_RS04315EL285_RS04320EL285_RS09040EL285_RS04295EL285_RS04300EL285_RS04305EL285_RS04310EL285_RS04325EL285_RS04330EL285_RS04335EL285_RS04340EL285_RS04345
Location: 988118..988426 (309 bp)
Type: Toxin
Protein ID: WP_026500960.1
Location: 988407..988691 (285 bp)
Type: Antitoxin
Protein ID: WP_005775091.1
Location: 983288..984580 (1293 bp)
Type: Others
Protein ID: WP_195890864.1
Location: 984612..985457 (846 bp)
Type: Others
Protein ID: WP_005775097.1
Location: 985459..985884 (426 bp)
Type: Others
Protein ID: WP_005775096.1
Location: 985884..987344 (1461 bp)
Type: Others
Protein ID: WP_005775095.1
Location: 987346..988053 (708 bp)
Type: Others
Protein ID: WP_005775094.1
Location: 988721..989101 (381 bp)
Type: Others
Protein ID: WP_005775090.1
Location: 989113..989493 (381 bp)
Type: Others
Protein ID: WP_005775089.1
Location: 989515..990642 (1128 bp)
Type: Others
Protein ID: WP_005775088.1
Location: 990731..991618 (888 bp)
Type: Others
Protein ID: WP_005775087.1
Location: 991632..993650 (2019 bp)
Type: Others
Protein ID: WP_026500959.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL285_RS09040983288..984580-1293WP_195890864.1hypothetical protein-
EL285_RS04295984612..985457-846WP_005775097.1hypothetical protein-
EL285_RS04300985459..985884-426WP_005775096.1hypothetical protein-
EL285_RS04305985884..987344-1461WP_005775095.1hypothetical protein-
EL285_RS04310987346..988053-708WP_005775094.1hypothetical protein-
EL285_RS04315988118..988426+309WP_026500960.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EL285_RS04320988407..988691+285WP_005775091.1putative addiction module antidote proteinAntitoxin
EL285_RS04325988721..989101-381WP_005775090.1hypothetical protein-
EL285_RS04330989113..989493-381WP_005775089.1hypothetical protein-
EL285_RS04335989515..990642-1128WP_005775088.1N4-gp56 family major capsid protein-
EL285_RS04340990731..991618-888WP_005775087.1hypothetical protein-
EL285_RS04345991632..993650-2019WP_026500959.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--971589..102395552366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(14-91)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11814.73 Da        Isoelectric Point: 8.8711

>T288011 WP_026500960.1 NZ_LR134527:988118-988426 [Bartonella elizabethae]
MMLIHKTIEFDTWLEKLKDKTAKAIILQRVVRLKQGLLGDVKFFHGIGELRIHYGAGYRVYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10230.74 Da        Isoelectric Point: 8.0048

>AT288011 WP_005775091.1 NZ_LR134527:988407-988691 [Bartonella elizabethae]
MKITPFEPEKYLKDIESQQIFLNEALKTGDAAHIADAIGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQPCNS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBJ1A1Y8

References