Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE(toxin)
Location 675119..675678 Replicon chromosome
Accession NZ_LR134527
Organism Bartonella elizabethae strain NCTC12898

Toxin (Protein)


Gene name parE Uniprot ID J0RIQ2
Locus tag EL285_RS02865 Protein ID WP_005773383.1
Coordinates 675119..675391 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J1A2Q4
Locus tag EL285_RS02870 Protein ID WP_005773384.1
Coordinates 675388..675678 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL285_RS02860 673962..674930 - 969 Protein_550 DUF3987 domain-containing protein -
EL285_RS02865 675119..675391 - 273 WP_005773383.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EL285_RS02870 675388..675678 - 291 WP_005773384.1 hypothetical protein Antitoxin
EL285_RS02875 675784..676488 - 705 WP_005773385.1 hypothetical protein -
EL285_RS02880 676591..676791 - 201 WP_005773386.1 DNA-binding protein -
EL285_RS02885 677002..678168 - 1167 WP_005773387.1 site-specific integrase -
EL285_RS02890 678337..678531 + 195 WP_005773388.1 hypothetical protein -
EL285_RS02895 678543..679544 + 1002 WP_005773389.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 636268..683884 47616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10576.49 Da        Isoelectric Point: 10.6238

>T288010 WP_005773383.1 NZ_LR134527:c675391-675119 [Bartonella elizabethae]
MKLIWTQVAHVDRKKIREYISQDNPSAALKFDQLLSEKVEKLVKFPTLGRLGRIENTRELIVNPNYIMIYDISNGVVRIL
RVLHTKQKFP

Download         Length: 273 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11120.54 Da        Isoelectric Point: 5.2454

>AT288010 WP_005773384.1 NZ_LR134527:c675678-675388 [Bartonella elizabethae]
MAETTFTFRVDDVLKNEFSKAAKACDRSGAQLLRDYMREIVKEQKEKSAHDLWFREQVQLGINSANVGDIISSEEIEAEA
REWRLKIQSKLDRSTL

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J0RIQ2

Antitoxin

Source ID Structure
AlphaFold DB J1A2Q4

References