Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE(toxin)
Location 675119..675678 Replicon chromosome
Accession NZ_LR134527
Organism Bartonella elizabethae strain NCTC12898

Toxin (Protein)


Gene name parE Uniprot ID J0RIQ2
Locus tag EL285_RS02865 Protein ID WP_005773383.1
Coordinates 675119..675391 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J1A2Q4
Locus tag EL285_RS02870 Protein ID WP_005773384.1
Coordinates 675388..675678 (-) Length 97 a.a.

Genomic Context

EL285_RS02890EL285_RS02895EL285_RS02860EL285_RS02865EL285_RS02870EL285_RS02875EL285_RS02880EL285_RS02885
Location: 678337..678531 (195 bp)
Type: Others
Protein ID: WP_005773388.1
Location: 678543..679544 (1002 bp)
Type: Others
Protein ID: WP_005773389.1
Location: 673962..674930 (969 bp)
Type: Others
Protein ID: Protein_550
Location: 675119..675391 (273 bp)
Type: Toxin
Protein ID: WP_005773383.1
Location: 675388..675678 (291 bp)
Type: Antitoxin
Protein ID: WP_005773384.1
Location: 675784..676488 (705 bp)
Type: Others
Protein ID: WP_005773385.1
Location: 676591..676791 (201 bp)
Type: Others
Protein ID: WP_005773386.1
Location: 677002..678168 (1167 bp)
Type: Others
Protein ID: WP_005773387.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL285_RS02860673962..674930-969Protein_550DUF3987 domain-containing protein-
EL285_RS02865675119..675391-273WP_005773383.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
EL285_RS02870675388..675678-291WP_005773384.1hypothetical proteinAntitoxin
EL285_RS02875675784..676488-705WP_005773385.1hypothetical protein-
EL285_RS02880676591..676791-201WP_005773386.1DNA-binding protein-
EL285_RS02885677002..678168-1167WP_005773387.1site-specific integrase-
EL285_RS02890678337..678531+195WP_005773388.1hypothetical protein-
EL285_RS02895678543..679544+1002WP_005773389.1phage tail protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--636268..68388447616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10576.49 Da        Isoelectric Point: 10.6238

>T288010 WP_005773383.1 NZ_LR134527:c675391-675119 [Bartonella elizabethae]
MKLIWTQVAHVDRKKIREYISQDNPSAALKFDQLLSEKVEKLVKFPTLGRLGRIENTRELIVNPNYIMIYDISNGVVRIL
RVLHTKQKFP

Download         Length: 273 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11120.54 Da        Isoelectric Point: 5.2454

>AT288010 WP_005773384.1 NZ_LR134527:c675678-675388 [Bartonella elizabethae]
MAETTFTFRVDDVLKNEFSKAAKACDRSGAQLLRDYMREIVKEQKEKSAHDLWFREQVQLGINSANVGDIISSEEIEAEA
REWRLKIQSKLDRSTL

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBJ0RIQ2

Antitoxin

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Source
ID
Structure
AlphaFold DBJ1A2Q4

References