288009

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 660965..661445 Replicon chromosome
Accession NZ_LR134527
Organism Bartonella elizabethae strain NCTC12898

Toxin (Protein)


Gene name pasB Uniprot ID J1A2R4
Locus tag EL285_RS02825 Protein ID WP_005773373.1
Coordinates 661176..661445 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID J0RIR3
Locus tag EL285_RS02820 Protein ID WP_005773372.1
Coordinates 660965..661192 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL285_RS02785 656531..656992 + 462 WP_078674257.1 hypothetical protein -
EL285_RS02790 657263..657781 + 519 WP_005773365.1 Rha family transcriptional regulator -
EL285_RS02795 657862..658563 + 702 WP_005773367.1 hypothetical protein -
EL285_RS02800 658633..658950 - 318 WP_005773368.1 type II toxin-antitoxin system HicB family antitoxin -
EL285_RS02805 658940..659218 - 279 WP_005773369.1 hypothetical protein -
EL285_RS02810 659877..660314 + 438 WP_005773370.1 single-stranded DNA-binding protein -
EL285_RS02815 660330..660866 + 537 WP_005773371.1 hypothetical protein -
EL285_RS02820 660965..661192 + 228 WP_005773372.1 ribbon-helix-helix protein, CopG family Antitoxin
EL285_RS02825 661176..661445 + 270 WP_005773373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL285_RS02830 661633..661968 + 336 WP_005773374.1 hypothetical protein -
EL285_RS02835 661970..663142 + 1173 WP_005773375.1 phage terminase large subunit -
EL285_RS02840 664607..665386 - 780 WP_005773376.1 hypothetical protein -
EL285_RS02845 665482..666102 - 621 WP_005773377.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 636268..683884 47616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10544.46 Da        Isoelectric Point: 10.2297

>T288009 WP_005773373.1 NZ_LR134527:661176-661445 [Bartonella elizabethae]
MVWTIRYEKKALSFLKKCDKKEARRIVDFLDQQIASLEDVRTIGKPLRGQLSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKS

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8784.86 Da        Isoelectric Point: 4.8898

>AT288009 WP_005773372.1 NZ_LR134527:660965-661192 [Bartonella elizabethae]
MTISIRLPSELETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERIRRGEATFYSSEEVRKELGLDD

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J1A2R4

Antitoxin

Source ID Structure
AlphaFold DB J0RIR3

References