288003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1874277..1874889 Replicon chromosome
Accession NZ_LR134520
Organism Streptococcus agalactiae strain NCTC13947

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag EL267_RS09675 Protein ID WP_000384859.1
Coordinates 1874554..1874889 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag EL267_RS09670 Protein ID WP_000259017.1
Coordinates 1874277..1874564 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL267_RS09620 1869369..1870229 - 861 WP_000477634.1 Rgg/GadR/MutR family transcriptional regulator -
EL267_RS09640 1871072..1871353 - 282 WP_000052406.1 hypothetical protein -
EL267_RS09645 1871387..1871773 - 387 WP_000259069.1 hypothetical protein -
EL267_RS09650 1871758..1872438 - 681 WP_001865565.1 hypothetical protein -
EL267_RS09655 1872411..1872971 - 561 WP_001865562.1 hypothetical protein -
EL267_RS09660 1872971..1873378 - 408 WP_000749954.1 hypothetical protein -
EL267_RS09665 1873480..1873770 - 291 WP_000078283.1 WXG100 family type VII secretion target -
EL267_RS09670 1874277..1874564 + 288 WP_000259017.1 hypothetical protein Antitoxin
EL267_RS09675 1874554..1874889 + 336 WP_000384859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL267_RS09680 1875194..1875664 - 471 WP_000130119.1 hypothetical protein -
EL267_RS09685 1875832..1877088 - 1257 WP_000122836.1 plasmid recombination protein -
EL267_RS09690 1877405..1877839 - 435 WP_001220479.1 hypothetical protein -
EL267_RS09695 1877875..1878750 - 876 WP_000421240.1 hypothetical protein -
EL267_RS09705 1879050..1879691 - 642 WP_000591144.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1874132..1882725 8593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T288003 WP_000384859.1 NZ_LR134520:1874554-1874889 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT288003 WP_000259017.1 NZ_LR134520:1874277-1874564 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References