Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 87833..88457 Replicon chromosome
Accession NZ_LR134520
Organism Streptococcus agalactiae strain NCTC13947

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag EL267_RS00560 Protein ID WP_000253103.1
Coordinates 88110..88457 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag EL267_RS00555 Protein ID WP_000543070.1
Coordinates 87833..88120 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL267_RS00525 83672..85174 + 1503 WP_121205208.1 DNA primase family protein -
EL267_RS00530 85539..86084 + 546 WP_000173125.1 hypothetical protein -
EL267_RS00535 86158..86646 + 489 WP_000891149.1 hypothetical protein -
EL267_RS00545 87050..87412 + 363 WP_121205210.1 DUF1492 domain-containing protein -
EL267_RS00550 87387..87764 + 378 WP_000038826.1 DUF1492 domain-containing protein -
EL267_RS00555 87833..88120 + 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL267_RS00560 88110..88457 + 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL267_RS00565 88940..89236 + 297 WP_000365227.1 DUF4298 domain-containing protein -
EL267_RS00570 89259..89798 - 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
EL267_RS00575 89937..92255 + 2319 WP_000883418.1 YhgE/Pip domain-containing protein -
EL267_RS00580 92322..92678 + 357 WP_000105931.1 DUF1304 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 71028..98397 27369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T288001 WP_000253103.1 NZ_LR134520:88110-88457 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT288001 WP_000543070.1 NZ_LR134520:87833-88120 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References