287996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 860222..860744 Replicon chromosome
Accession NZ_LR134517
Organism Helicobacter pylori strain NCTC13345

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag EL256_RS04085 Protein ID WP_000271050.1
Coordinates 860222..860506 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EL256_RS04090 Protein ID WP_080276408.1
Coordinates 860487..860744 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL256_RS04060 855372..856445 - 1074 WP_197721173.1 glycosyltransferase family 8 protein -
EL256_RS04065 856768..857535 - 768 WP_000242348.1 ABC transporter ATP-binding protein -
EL256_RS04070 857535..858515 - 981 WP_000921461.1 iron ABC transporter permease -
EL256_RS04075 858508..859362 - 855 WP_126442762.1 SDR family oxidoreductase -
EL256_RS04080 859503..860027 + 525 WP_126442764.1 acyl-CoA thioesterase -
EL256_RS04085 860222..860506 - 285 WP_000271050.1 endoribonuclease VapD Toxin
EL256_RS04090 860487..860744 - 258 WP_080276408.1 hypothetical protein Antitoxin
EL256_RS08120 860729..860866 - 138 WP_164758918.1 hypothetical protein -
EL256_RS04100 861601..863847 - 2247 WP_126442766.1 Hop family adhesin BabA -
EL256_RS04120 865159..865430 - 272 Protein_770 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T287996 WP_000271050.1 NZ_LR134517:c860506-860222 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9779.04 Da        Isoelectric Point: 4.6909

>AT287996 WP_080276408.1 NZ_LR134517:c860744-860487 [Helicobacter pylori]
MAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHETPNIETQQAMREALNGINLTQIDSLDDFTNELKRENSKGFEN
VCFSV

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure

References