Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1419406..1419989 Replicon chromosome
Accession NZ_LR134516
Organism Neisseria animaloris strain NCTC12227

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL276_RS06480 Protein ID WP_126304797.1
Coordinates 1419406..1419657 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL276_RS06485 Protein ID WP_107928840.1
Coordinates 1419654..1419989 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL276_RS06455 1414611..1415783 + 1173 WP_197720742.1 MFS transporter -
EL276_RS06460 1415890..1416555 - 666 WP_126304794.1 deoxyribose-phosphate aldolase -
EL276_RS06465 1416663..1417391 - 729 WP_126304795.1 ribonuclease PH -
EL276_RS06470 1417491..1418363 + 873 WP_172594900.1 YicC family protein -
EL276_RS06475 1418461..1419237 + 777 WP_126304796.1 ferredoxin--NADP reductase -
EL276_RS06480 1419406..1419657 + 252 WP_126304797.1 type II toxin-antitoxin system HicA family toxin Toxin
EL276_RS06485 1419654..1419989 + 336 WP_107928840.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL276_RS06490 1420151..1421512 - 1362 WP_126304798.1 PFL family protein -
EL276_RS06495 1421525..1421797 - 273 WP_085390275.1 ACT domain-containing protein -
EL276_RS06500 1421891..1422268 - 378 WP_126304799.1 holo-ACP synthase -
EL276_RS06505 1422316..1423047 - 732 WP_126304800.1 pyridoxine 5'-phosphate synthase -
EL276_RS06510 1423100..1423846 - 747 WP_126304801.1 DNA repair protein RecO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(22-74)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9350.76 Da        Isoelectric Point: 10.0139

>T287994 WP_126304797.1 NZ_LR134516:1419406-1419657 [Neisseria animaloris]
MKKHQRTLASIFSRPVSGSIKWADIEALFIELDAEIQEREGSRIAVILFGQVKVFHRPHPSPDTDKGAVASVRKWLEENG
VKP

Download         Length: 252 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12090.53 Da        Isoelectric Point: 5.5565

>AT287994 WP_107928840.1 NZ_LR134516:1419654-1419989 [Neisseria animaloris]
MNNVMEINGHKAIIQYDPETELLRGEFIGLNGGADFYADNVADLHKEGAASLAVFLDVCKEKGIEPYKQYSGRFNVRVSP
ETHAAAAAAAASQNISLNEWVNRAIRQCAHG

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References