Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 919354..919998 Replicon chromosome
Accession NZ_LR134516
Organism Neisseria animaloris strain NCTC12227

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL276_RS04175 Protein ID WP_107879149.1
Coordinates 919354..919749 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL276_RS04180 Protein ID WP_085356725.1
Coordinates 919753..919998 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL276_RS04140 915443..916318 - 876 WP_126304430.1 pirin family protein -
EL276_RS04145 916368..916604 - 237 WP_085356720.1 DUF896 domain-containing protein -
EL276_RS04150 916800..917153 + 354 WP_085356721.1 helix-turn-helix transcriptional regulator -
EL276_RS04155 917397..917933 - 537 WP_085356722.1 inorganic diphosphatase -
EL276_RS04160 918042..918362 - 321 WP_054600303.1 iron-sulfur cluster assembly protein IscA -
EL276_RS04165 918549..918785 - 237 WP_126304432.1 recombinase RecA -
EL276_RS04170 918845..919228 - 384 WP_085360421.1 Fe-S cluster assembly scaffold IscU -
EL276_RS04175 919354..919749 - 396 WP_107879149.1 type II toxin-antitoxin system VapC family toxin Toxin
EL276_RS04180 919753..919998 - 246 WP_085356725.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL276_RS04185 920103..921317 - 1215 WP_126304434.1 IscS subfamily cysteine desulfurase -
EL276_RS04190 921353..921796 - 444 WP_126304436.1 Fe-S cluster assembly transcriptional regulator IscR -
EL276_RS04195 922191..923348 + 1158 WP_085389824.1 alpha-hydroxy-acid oxidizing protein -
EL276_RS04200 923451..924461 - 1011 WP_126304438.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(7-38)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14448.69 Da        Isoelectric Point: 7.5692

>T287993 WP_107879149.1 NZ_LR134516:c919749-919354 [Neisseria animaloris]
MRYLLDTNIVSHILRRQPNVMAKLQSVPMSDLHISAVTHAELMYGLAKKPDAAKLHRAVHELLLRISVLPFDEQASTHYG
KFKAQAEQSGKNLASLDMMIAAHASAVSAVLVSNDAAFQQIADLSVEDWTK

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9251.10 Da        Isoelectric Point: 4.1834

>AT287993 WP_085356725.1 NZ_LR134516:c919998-919753 [Neisseria animaloris]
MQTAKLFQNGRSQAVRLPAAFRFTGDEVYIRRDEATGDVILSQRPSDWQGFIAAASELDESDTIERDTSIQQRDPFADWQ
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References