Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2099463..2100178 Replicon chromosome
Accession NZ_LR134515
Organism Actinobacillus pleuropneumoniae strain NCTC10976

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL265_RS10020 Protein ID WP_005619039.1
Coordinates 2099463..2099891 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BT01
Locus tag EL265_RS10025 Protein ID WP_005599447.1
Coordinates 2099891..2100178 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL265_RS10005 2095048..2096754 - 1707 WP_005602678.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
EL265_RS10010 2096850..2097131 - 282 WP_005599441.1 DNA-directed RNA polymerase subunit omega -
EL265_RS10015 2097258..2099339 - 2082 WP_005602680.1 ATP-dependent DNA helicase RecG -
EL265_RS10020 2099463..2099891 - 429 WP_005619039.1 type II toxin-antitoxin system VapC family toxin Toxin
EL265_RS10025 2099891..2100178 - 288 WP_005599447.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL265_RS10030 2100384..2102099 + 1716 WP_005602682.1 proline--tRNA ligase -
EL265_RS10035 2102165..2102353 - 189 WP_005602684.1 hypothetical protein -
EL265_RS10040 2102356..2102937 - 582 WP_005599450.1 sigma-70 family RNA polymerase sigma factor -
EL265_RS10045 2103026..2103982 + 957 WP_005619040.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
EL265_RS10050 2103982..2104575 + 594 WP_005599453.1 sulfoxide reductase heme-binding subunit YedZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16508.97 Da        Isoelectric Point: 8.9724

>T287991 WP_005619039.1 NZ_LR134515:c2099891-2099463 [Actinobacillus pleuropneumoniae]
MFQYLFDTNIISELYKLGSNRMDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQA
KSFSINNEIALLASEYHIPNKMDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11040.29 Da        Isoelectric Point: 4.5578

>AT287991 WP_005599447.1 NZ_LR134515:c2100178-2099891 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N3C5

References