Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2002361..2002989 Replicon chromosome
Accession NZ_LR134515
Organism Actinobacillus pleuropneumoniae strain NCTC10976

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL265_RS09445 Protein ID WP_005602539.1
Coordinates 2002591..2002989 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3S5F5Z7
Locus tag EL265_RS09440 Protein ID WP_005602537.1
Coordinates 2002361..2002591 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL265_RS09430 1999668..2001218 + 1551 WP_005602533.1 class I SAM-dependent methyltransferase -
EL265_RS09435 2001215..2001997 + 783 WP_005602534.1 HincII family type II restriction endonuclease -
EL265_RS11225 2002113..2002253 - 141 WP_005602535.1 hypothetical protein -
EL265_RS09440 2002361..2002591 + 231 WP_005602537.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL265_RS09445 2002591..2002989 + 399 WP_005602539.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL265_RS09450 2003125..2003541 - 417 WP_005602541.1 DUF417 family protein -
EL265_RS09455 2003787..2004437 + 651 WP_005602543.1 DUF2202 domain-containing protein -
EL265_RS09460 2004617..2005396 - 780 WP_005602546.1 hypothetical protein -
EL265_RS09465 2005469..2006791 - 1323 WP_005620148.1 HslU--HslV peptidase ATPase subunit -
EL265_RS09470 2006937..2007458 - 522 WP_005613306.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1987323..2033662 46339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15003.30 Da        Isoelectric Point: 8.0810

>T287990 WP_005602539.1 NZ_LR134515:2002591-2002989 [Actinobacillus pleuropneumoniae]
MLAYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLRAFERVEGLRLDNWV

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8591.74 Da        Isoelectric Point: 4.7063

>AT287990 WP_005602537.1 NZ_LR134515:2002361-2002591 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLSSATVSDDFMTEREISIQPEREGL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5F5Z7

References