Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1787790..1788521 Replicon chromosome
Accession NZ_LR134515
Organism Actinobacillus pleuropneumoniae strain NCTC10976

Toxin (Protein)


Gene name tacT Uniprot ID A0A448U107
Locus tag EL265_RS08385 Protein ID WP_005602211.1
Coordinates 1787790..1788257 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag EL265_RS08390 Protein ID WP_005619269.1
Coordinates 1788261..1788521 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL265_RS08360 1783149..1783520 - 372 WP_005598830.1 CrcB family protein -
EL265_RS08365 1783523..1784587 - 1065 WP_005602204.1 MFS transporter -
EL265_RS08370 1784682..1785791 + 1110 WP_005602206.1 anhydro-N-acetylmuramic acid kinase -
EL265_RS08375 1785845..1786759 + 915 WP_005602207.1 N-acetylmuramic acid 6-phosphate etherase -
EL265_RS08380 1786826..1787707 - 882 WP_005602209.1 50S ribosomal protein L11 methyltransferase -
EL265_RS08385 1787790..1788257 - 468 WP_005602211.1 GNAT family N-acetyltransferase Toxin
EL265_RS08390 1788261..1788521 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
EL265_RS08395 1788642..1790102 - 1461 WP_005598844.1 metalloprotease TldD -
EL265_RS08400 1790232..1791491 + 1260 WP_005615928.1 tRNA lysidine(34) synthetase TilS -
EL265_RS08405 1791518..1791808 - 291 WP_005602215.1 DUF5389 family protein -
EL265_RS08410 1791810..1792703 - 894 WP_005598850.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17192.19 Da        Isoelectric Point: 8.9312

>T287989 WP_005602211.1 NZ_LR134515:c1788257-1787790 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT287989 WP_005619269.1 NZ_LR134515:c1788521-1788261 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448U107

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References