Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1581124..1581769 Replicon chromosome
Accession NZ_LR134515
Organism Actinobacillus pleuropneumoniae strain NCTC10976

Toxin (Protein)


Gene name toxT Uniprot ID B0BQU7
Locus tag EL265_RS07360 Protein ID WP_005619674.1
Coordinates 1581398..1581769 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag EL265_RS07355 Protein ID WP_005598477.1
Coordinates 1581124..1581417 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL265_RS07325 1576456..1577139 - 684 WP_005601946.1 arginine ABC transporter permease ArtM -
EL265_RS07330 1577139..1577810 - 672 WP_005601949.1 arginine ABC transporter permease ArtQ -
EL265_RS07335 1577816..1578550 - 735 WP_005601951.1 transporter substrate-binding domain-containing protein -
EL265_RS07340 1578555..1579289 - 735 WP_005598473.1 arginine ABC transporter ATP-binding protein ArtP -
EL265_RS07345 1579514..1580011 - 498 WP_005601953.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
EL265_RS07350 1580084..1581046 + 963 WP_005619672.1 calcium/sodium antiporter -
EL265_RS07355 1581124..1581417 - 294 WP_005598477.1 helix-turn-helix domain-containing protein Antitoxin
EL265_RS07360 1581398..1581769 - 372 WP_005619674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL265_RS07365 1581963..1583714 + 1752 WP_005601957.1 protein-disulfide reductase DsbD -
EL265_RS07370 1583772..1584341 + 570 WP_005601959.1 elongation factor P hydroxylase -
EL265_RS07375 1584385..1585239 - 855 WP_005598486.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15066.57 Da        Isoelectric Point: 10.4054

>T287988 WP_005619674.1 NZ_LR134515:c1581769-1581398 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10935.81 Da        Isoelectric Point: 10.3120

>AT287988 WP_005598477.1 NZ_LR134515:c1581417-1581124 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N206

Antitoxin

Source ID Structure

References