Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1485719..1486227 Replicon chromosome
Accession NZ_LR134515
Organism Actinobacillus pleuropneumoniae strain NCTC10976

Toxin (Protein)


Gene name relE Uniprot ID B0BQK9
Locus tag EL265_RS06880 Protein ID WP_005605064.1
Coordinates 1485967..1486227 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0BQK8
Locus tag EL265_RS06875 Protein ID WP_005598318.1
Coordinates 1485719..1485970 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL265_RS06840 1481381..1481929 - 549 WP_005601803.1 type IV pilus biogenesis/stability protein PilW -
EL265_RS06845 1481983..1483164 - 1182 WP_005601805.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
EL265_RS06865 1483942..1485381 + 1440 WP_005601815.1 glutamate--tRNA ligase -
EL265_RS06875 1485719..1485970 + 252 WP_005598318.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL265_RS06880 1485967..1486227 + 261 WP_005605064.1 Txe/YoeB family addiction module toxin Toxin
EL265_RS06885 1486386..1486553 - 168 WP_005598320.1 Trm112 family protein -
EL265_RS06890 1486555..1487535 - 981 WP_005601819.1 tetraacyldisaccharide 4'-kinase -
EL265_RS06895 1487629..1488888 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
EL265_RS06900 1488888..1489478 - 591 WP_005601821.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
EL265_RS06905 1489602..1489994 + 393 WP_005618838.1 SufE family protein -
EL265_RS06920 1490353..1491126 - 774 WP_005618837.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.99 Da        Isoelectric Point: 8.0109

>T287987 WP_005605064.1 NZ_LR134515:1485967-1486227 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9362.66 Da        Isoelectric Point: 4.5659

>AT287987 WP_005598318.1 NZ_LR134515:1485719-1485970 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0BQK9

Antitoxin

Source ID Structure
AlphaFold DB B0BQK8

References