Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 237992..238604 Replicon chromosome
Accession NZ_LR134512
Organism Streptococcus agalactiae strain NCTC13949

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag EL254_RS01430 Protein ID WP_000384859.1
Coordinates 237992..238327 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag EL254_RS01435 Protein ID WP_000259017.1
Coordinates 238317..238604 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL254_RS01400 233178..233819 + 642 WP_000591144.1 hypothetical protein -
EL254_RS01410 234131..235006 + 876 WP_000421240.1 hypothetical protein -
EL254_RS01415 235042..235476 + 435 WP_001220479.1 hypothetical protein -
EL254_RS01420 235793..237049 + 1257 WP_000122836.1 plasmid recombination protein -
EL254_RS01425 237217..237687 + 471 WP_000130119.1 hypothetical protein -
EL254_RS01430 237992..238327 - 336 WP_000384859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL254_RS01435 238317..238604 - 288 WP_000259017.1 hypothetical protein Antitoxin
EL254_RS01440 239111..239401 + 291 WP_000078283.1 WXG100 family type VII secretion target -
EL254_RS01445 239503..239910 + 408 WP_000749954.1 hypothetical protein -
EL254_RS01450 239910..240470 + 561 WP_001865562.1 hypothetical protein -
EL254_RS01455 240443..241123 + 681 WP_001865565.1 hypothetical protein -
EL254_RS01460 241108..241494 + 387 WP_000259069.1 hypothetical protein -
EL254_RS01465 241528..241809 + 282 WP_000052406.1 hypothetical protein -
EL254_RS01485 242652..243512 + 861 WP_000477634.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T287984 WP_000384859.1 NZ_LR134512:c238327-237992 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT287984 WP_000259017.1 NZ_LR134512:c238604-238317 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References