Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2250598..2251187 Replicon chromosome
Accession NZ_LR134503
Organism Kaistella jeonii strain NCTC13459

Toxin (Protein)


Gene name PumA Uniprot ID A0A0C1FAP5
Locus tag EL270_RS10350 Protein ID WP_039350354.1
Coordinates 2250888..2251187 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C1FQU5
Locus tag EL270_RS10345 Protein ID WP_039350579.1
Coordinates 2250598..2250882 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL270_RS10310 2246041..2246418 - 378 WP_039350335.1 group III truncated hemoglobin -
EL270_RS10315 2246630..2247574 + 945 WP_039350339.1 Inward rectifier potassium channel Irk -
EL270_RS10320 2247574..2248065 + 492 WP_039350342.1 YkgJ family cysteine cluster protein -
EL270_RS10325 2248175..2248444 + 270 WP_126340468.1 hypothetical protein -
EL270_RS10330 2248564..2248980 - 417 WP_039350346.1 hypothetical protein -
EL270_RS10335 2249147..2249914 - 768 WP_169743943.1 DUF4249 family protein -
EL270_RS10340 2250134..2250412 - 279 WP_039350351.1 carboxypeptidase-like regulatory domain-containing protein -
EL270_RS10345 2250598..2250882 - 285 WP_039350579.1 putative addiction module antidote protein Antitoxin
EL270_RS10350 2250888..2251187 - 300 WP_039350354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL270_RS10355 2251402..2251947 - 546 WP_039350356.1 GNAT family N-acetyltransferase -
EL270_RS10360 2252097..2252744 - 648 WP_052257410.1 hypothetical protein -
EL270_RS10365 2253047..2253460 - 414 WP_039350360.1 hypothetical protein -
EL270_RS10370 2254852..2255529 - 678 WP_039350367.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2230990..2283551 52561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11862.83 Da        Isoelectric Point: 10.1202

>T287982 WP_039350354.1 NZ_LR134503:c2251187-2250888 [Kaistella jeonii]
MYFIEKTEEFDKWFRKLNDLRAKAKILFRIQKLETDEHFGDFKPVGNGINELKINYAKGYRIYFKETEGKIIILLIGGDK
STQQKDIEKAFQIWNKLKK

Download         Length: 300 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10059.51 Da        Isoelectric Point: 4.5026

>AT287982 WP_039350579.1 NZ_LR134503:c2250882-2250598 [Kaistella jeonii]
MNTTKFDIADYLDNNEMIAEYLNTVLEEGNDSDIIVAIGTVAKAIGMTKIAEETGLSRPSLYKALSDGAKPQFATIMKVL
KAVGGQLHVNPTTA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1FAP5

Antitoxin

Source ID Structure
AlphaFold DB A0A0C1FQU5

References