Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2090204..2090854 Replicon chromosome
Accession NZ_LR134495
Organism Mannheimia haemolytica strain NCTC10643

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL242_RS10220 Protein ID WP_126302496.1
Coordinates 2090204..2090593 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL242_RS10225 Protein ID WP_126302497.1
Coordinates 2090594..2090854 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL242_RS10170 2085548..2086357 - 810 WP_126302492.1 metal ABC transporter permease -
EL242_RS10175 2086350..2087210 - 861 WP_126302493.1 metal ABC transporter permease -
EL242_RS10180 2087284..2088069 - 786 WP_126302494.1 GDP-L-fucose synthase -
EL242_RS10215 2088934..2090172 - 1239 WP_126302495.1 peptidase T -
EL242_RS10220 2090204..2090593 - 390 WP_126302496.1 type II toxin-antitoxin system VapC family toxin Toxin
EL242_RS10225 2090594..2090854 - 261 WP_126302497.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL242_RS10230 2090965..2091177 - 213 WP_126302498.1 BrnA antitoxin family protein -
EL242_RS10235 2091324..2091713 - 390 WP_172595359.1 helix-turn-helix domain-containing protein -
EL242_RS10240 2091816..2092073 + 258 WP_126302500.1 hypothetical protein -
EL242_RS10245 2092087..2092260 + 174 WP_126302501.1 excalibur calcium-binding domain-containing protein -
EL242_RS10250 2092315..2095836 - 3522 WP_126302502.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14635.92 Da        Isoelectric Point: 7.1040

>T287979 WP_126302496.1 NZ_LR134495:c2090593-2090204 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNTNVVAKLKSINPEKLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10187.46 Da        Isoelectric Point: 4.6909

>AT287979 WP_126302497.1 NZ_LR134495:c2090854-2090594 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNAEHWQKLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References