Detailed information of TA system TA287973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 4105516..4107320
• Replicon: chromosome
• Accession: NZ_LR134494
• Organism: Serratia quinivorans strain NCTC13188

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: EL336_RS19390
• Protein ID: WP_112362807.1
• Coordinates: 4105516..4106865 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: EL336_RS19395
• Protein ID: WP_112362808.1
• Coordinates: 4106862..4107320 (+)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL336_RS19360	4101077..4102738	+	1662	WP_167470794.1	DNA repair protein RecN	-
EL336_RS19365	4102852..4103190	+	339	WP_012146393.1	outer membrane protein assembly factor BamE	-
EL336_RS19370	4103305..4103589	-	285	WP_112362806.1	RnfH family protein	-
EL336_RS19375	4103582..4104016	-	435	WP_012146395.1	type II toxin-antitoxin system RatA family toxin	-
EL336_RS19380	4104178..4104660	+	483	WP_012146396.1	SsrA-binding protein SmpB	-
EL336_RS19390	4105516..4106865	+	1350	WP_112362807.1	type II toxin-antitoxin system HipA family toxin	Toxin
EL336_RS19395	4106862..4107320	+	459	WP_112362808.1	helix-turn-helix domain-containing protein	Antitoxin
EL336_RS19400	4107410..4108546	-	1137	WP_112362809.1	HlyD family secretion protein	-
EL336_RS19405	4108556..4108903	-	348	WP_112348568.1	DUF3302 domain-containing protein	-
EL336_RS19410	4108943..4109596	-	654	WP_112362810.1	DUF3313 domain-containing protein	-
EL336_RS19415	4109734..4110669	+	936	WP_112362811.1	LysR family transcriptional regulator	-
EL336_RS19420	4110871..4111251	+	381	WP_012146403.1	Spy/CpxP family protein refolding chaperone	-
EL336_RS19425	4111412..4112092	+	681	WP_012146404.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-408)

Antitoxin

• Cro/C1-type helix-turn-helix domain (81-134)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51556.54 Da
• Isoelectric Point: 5.1457

>T287973 WP_112362807.1 NZ_LR134494:4105516-4106865 [Serratia quinivorans]
METLTLQAFLNNQWINVANIAFPDGEQQSYKITELHYHTDFAIDYLDRDDNHAVSINHPVSLFFEDEGPRGWMKFLDDIV
PSGSSRRYWLKYLDIDELTPGQQDFVLLKYGTMSPVGNLRIKESLAEANPLANRLFFSIEDIKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRCSHDERIWIDTFQNDLTNRDIPYLVKYPRGRKTEIDCNIVRAEFHYYHELEAMGFNTISTQHMR
LEEGITYPSIWLPRFDICFETADKVKRFGMESVYSMLKKTAGTTLDQEITIRTLIEKITQSNMVTEHGFDFDVREFVIEW
VRRDLLNIIFGNSDNHGRNTSFIKDSFSIQLAPIYDFAPMKADPEGIPRTTKWAQKLEVGGEYNYEAITAALADLVPENE
LMHALKTTAKQLIGLKERLQNRGVPRQIIEMPSIGFDYIPEKLKKWGLL

Nucleotide

• Length: 1350 bp

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 17045.45 Da
• Isoelectric Point: 10.6168

>AT287973 WP_112362808.1 NZ_LR134494:4106862-4107320 [Serratia quinivorans]
MKTPEKMSDSARVTINRLREKNKANYKENSSISDVKNEVNSEKERGRQRASGTSKSMGAIERNSARHNIMKLLLLGEITQ
GQALKTLRVDVLGLKQENYATLVSVSRKTLSEIENDRGNYTSDIINKVFKPFGLQVGLVPISRHTLSTLLNE

Nucleotide

• Length: 459 bp