Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3957911..3958563 Replicon chromosome
Accession NZ_LR134494
Organism Serratia quinivorans strain NCTC13188

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL336_RS18700 Protein ID WP_112364039.1
Coordinates 3957911..3958297 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2X2J553
Locus tag EL336_RS18705 Protein ID WP_012146268.1
Coordinates 3958300..3958563 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL336_RS18685 3954386..3955816 + 1431 WP_112364040.1 MFS transporter -
EL336_RS18690 3955816..3957198 + 1383 WP_012146265.1 two-component system sensor histidine kinase BaeS -
EL336_RS18695 3957198..3957914 + 717 WP_041418654.1 two-component system response regulator BaeR -
EL336_RS18700 3957911..3958297 - 387 WP_112364039.1 type II toxin-antitoxin system VapC family toxin Toxin
EL336_RS18705 3958300..3958563 - 264 WP_012146268.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL336_RS18710 3958916..3959254 + 339 WP_112364038.1 YegP family protein -
EL336_RS18715 3959433..3960785 + 1353 WP_112364037.1 tRNA 5-hydroxyuridine modification protein YegQ -
EL336_RS18720 3961272..3962189 + 918 WP_112364036.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14082.32 Da        Isoelectric Point: 7.8792

>T287972 WP_112364039.1 NZ_LR134494:c3958297-3957911 [Serratia quinivorans]
MYMFDTNTVSQLFRRHPRLLGLMEKIPPSAVCISSITEAELLYGVAKRQSLTLKATVAAFLDSVTVYAWDSEAAHCYGAM
RAEMTKNGRVMRALDQLIAAHAQSRGATIVTNDKAFAMVPGLAVEDWT

Download         Length: 387 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10098.43 Da        Isoelectric Point: 5.1351

>AT287972 WP_012146268.1 NZ_LR134494:c3958563-3958300 [Serratia quinivorans]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIAQTQVPQDFLTAEDRQQGMATR
DPFAGEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2J553

References