Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1159051..1159678 Replicon chromosome
Accession NZ_LR134494
Organism Serratia quinivorans strain NCTC13188

Toxin (Protein)


Gene name Hha Uniprot ID A0A2X2GU35
Locus tag EL336_RS05515 Protein ID WP_012005558.1
Coordinates 1159051..1159254 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag EL336_RS05520 Protein ID WP_004940312.1
Coordinates 1159310..1159678 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL336_RS05500 1154690..1156033 - 1344 WP_112362757.1 NCS2 family permease -
EL336_RS05505 1156116..1157903 - 1788 WP_112362758.1 adenine deaminase -
EL336_RS05510 1158041..1158973 + 933 WP_012005557.1 LysR family transcriptional regulator -
EL336_RS05515 1159051..1159254 - 204 WP_012005558.1 hemolysin expression modulator Hha Toxin
EL336_RS05520 1159310..1159678 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
EL336_RS05525 1159841..1160167 - 327 WP_112362759.1 hypothetical protein -
EL336_RS05530 1160644..1161357 + 714 WP_126501364.1 ABC transporter ATP-binding protein -
EL336_RS05535 1161354..1162211 + 858 WP_012005561.1 metal ABC transporter permease -
EL336_RS05540 1162237..1163115 + 879 WP_112362761.1 metal ABC transporter substrate-binding protein -
EL336_RS05545 1163229..1163369 - 141 WP_012005563.1 type B 50S ribosomal protein L36 -
EL336_RS05550 1163382..1163639 - 258 WP_012005564.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8101.45 Da        Isoelectric Point: 6.9770

>T287965 WP_012005558.1 NZ_LR134494:c1159254-1159051 [Serratia quinivorans]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT287965 WP_004940312.1 NZ_LR134494:c1159678-1159310 [Serratia quinivorans]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2GU35

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References