Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 949222..949778 Replicon chromosome
Accession NZ_LR134494
Organism Serratia quinivorans strain NCTC13188

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag EL336_RS04505 Protein ID WP_012005370.1
Coordinates 949222..949512 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X2GF13
Locus tag EL336_RS04510 Protein ID WP_012005371.1
Coordinates 949500..949778 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL336_RS04485 944269..945219 - 951 WP_115183223.1 acetyltransferase -
EL336_RS04490 945216..946961 - 1746 WP_126501334.1 IucA/IucC family siderophore biosynthesis protein -
EL336_RS04495 947099..948322 + 1224 WP_126501336.1 MFS transporter -
EL336_RS04500 948328..949212 + 885 WP_126501338.1 siderophore-interacting protein -
EL336_RS04505 949222..949512 - 291 WP_012005370.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL336_RS04510 949500..949778 - 279 WP_012005371.1 ribbon-helix-helix protein, CopG family Antitoxin
EL336_RS04515 949864..950250 - 387 WP_126501340.1 oxalurate catabolism protein HpxZ -
EL336_RS04520 950254..951654 - 1401 WP_126501342.1 AtzE family amidohydrolase -
EL336_RS04525 951651..951842 - 192 WP_017891721.1 oxalurate catabolism protein HpxX -
EL336_RS04530 951868..953454 - 1587 WP_126501344.1 gamma-glutamyltransferase family protein -
EL336_RS04535 953600..954439 + 840 WP_126501346.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10956.40 Da        Isoelectric Point: 6.6416

>T287964 WP_012005370.1 NZ_LR134494:c949512-949222 [Serratia quinivorans]
VPQLIWTPAALQDIQRLYRFLAEKDLNSAKRAVATIRHSVNILAHQPQVGRPVEEMDTEFREWPIDFGNSGYIALYHFDG
HTAVLLAVRHQSEAGY

Download         Length: 291 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10850.09 Da        Isoelectric Point: 5.2246

>AT287964 WP_012005371.1 NZ_LR134494:c949778-949500 [Serratia quinivorans]
MTSATSIKIDEQLKQRVQQIAATRQRSAHWIMREAIREYVEREEKREALRKDALQAWEVYQANGKHLSQEEADNWLISLE
KGDDTEIPECHN

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2GF13

References