287953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1688367..1688956 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag EL230_RS08520 Protein ID WP_005653200.1
Coordinates 1688708..1688956 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag EL230_RS08515 Protein ID WP_005653201.1
Coordinates 1688367..1688711 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS08500 1683591..1684985 - 1395 WP_038439957.1 sodium-coupled multidrug efflux MATE transporter HmrM -
EL230_RS08505 1685029..1685643 + 615 WP_126513652.1 riboflavin synthase -
EL230_RS08510 1685714..1688323 - 2610 WP_126513653.1 aminopeptidase N -
EL230_RS08515 1688367..1688711 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL230_RS08520 1688708..1688956 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
EL230_RS08525 1689127..1689621 + 495 WP_065251031.1 5-(carboxyamino)imidazole ribonucleotide mutase -
EL230_RS08530 1689691..1690779 + 1089 WP_126513654.1 5-(carboxyamino)imidazole ribonucleotide synthase -
EL230_RS08535 1690918..1692108 + 1191 WP_126513655.1 aspartate/tyrosine/aromatic aminotransferase -
EL230_RS08540 1692213..1692839 - 627 WP_126513656.1 energy-coupling factor ABC transporter ATP-binding protein -
EL230_RS08545 1692841..1693473 - 633 WP_126513657.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T287953 WP_005653200.1 NZ_LR134490:c1688956-1688708 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT287953 WP_005653201.1 NZ_LR134490:c1688711-1688367 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References