Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 739189..739826 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name VapC1 Uniprot ID E4QWH2
Locus tag EL230_RS03740 Protein ID WP_005649049.1
Coordinates 739189..739593 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID E4QWH3
Locus tag EL230_RS03745 Protein ID WP_005649046.1
Coordinates 739590..739826 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS03710 734745..735311 + 567 WP_005544066.1 elongation factor P -
EL230_RS03720 735659..736252 - 594 WP_005666656.1 primosomal replication protein -
EL230_RS03725 736285..737637 - 1353 WP_126513485.1 Na+/H+ antiporter family protein -
EL230_RS03730 737952..738641 - 690 WP_005649060.1 ribonuclease T -
EL230_RS03735 738715..739122 - 408 WP_005654069.1 lactoylglutathione lyase -
EL230_RS03740 739189..739593 - 405 WP_005649049.1 type II toxin-antitoxin system VapC family toxin Toxin
EL230_RS03745 739590..739826 - 237 WP_005649046.1 antitoxin Antitoxin
EL230_RS03750 739919..740644 - 726 WP_005649042.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
EL230_RS03755 740697..741215 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
EL230_RS03760 741434..743200 + 1767 WP_005649039.1 aspartate--tRNA ligase -
EL230_RS03765 743222..743695 + 474 WP_005666660.1 dihydroneopterin triphosphate diphosphatase -
EL230_RS03770 743707..744447 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15692.29 Da        Isoelectric Point: 8.9777

>T287950 WP_005649049.1 NZ_LR134490:c739593-739189 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9037.19 Da        Isoelectric Point: 4.2342

>AT287950 WP_005649046.1 NZ_LR134490:c739826-739590 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E4QWH2

Antitoxin

Source ID Structure
AlphaFold DB E4QWH3

References