287949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 618448..618926 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name VapD Uniprot ID A0A0K9L551
Locus tag EL230_RS03110 Protein ID WP_050848517.1
Coordinates 618648..618926 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag EL230_RS03105 Protein ID WP_012055040.1
Coordinates 618448..618639 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS03085 614657..615640 + 984 WP_112089548.1 DNA polymerase III subunit delta' -
EL230_RS03090 615695..616477 + 783 WP_112089546.1 YchF/TatD family DNA exonuclease -
EL230_RS03095 616504..617028 + 525 WP_005649352.1 DUF1523 family protein -
EL230_RS03100 617079..618377 + 1299 WP_075985482.1 hemolysin family protein -
EL230_RS03105 618448..618639 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
EL230_RS03110 618648..618926 + 279 WP_050848517.1 virulence-associated protein VapD Toxin
EL230_RS03115 619022..619552 + 531 WP_048954868.1 hypothetical protein -
EL230_RS03120 619622..621121 + 1500 WP_126513461.1 fused PTS fructose transporter subunit IIA/HPr protein -
EL230_RS03125 621123..622064 + 942 WP_126513462.1 1-phosphofructokinase -
EL230_RS03130 622066..623736 + 1671 WP_126513463.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10604.98 Da        Isoelectric Point: 5.7408

>T287949 WP_050848517.1 NZ_LR134490:618648-618926 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNSLKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT287949 WP_012055040.1 NZ_LR134490:618448-618639 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L551

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References