Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 411864..412374 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag EL230_RS02065 Protein ID WP_005650834.1
Coordinates 411864..412085 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag EL230_RS02070 Protein ID WP_005650837.1
Coordinates 412078..412374 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS02060 408752..411757 + 3006 WP_126513438.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
EL230_RS02065 411864..412085 + 222 WP_005650834.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL230_RS02070 412078..412374 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
EL230_RS02075 412558..414474 + 1917 WP_126513439.1 ABC transporter ATP-binding protein -
EL230_RS02080 414484..415032 + 549 WP_005667615.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
EL230_RS02085 415048..415599 + 552 WP_126513440.1 Sua5/YciO/YrdC/YwlC family protein -
EL230_RS02090 415603..416421 + 819 WP_126513441.1 shikimate dehydrogenase -
EL230_RS02095 416418..416981 + 564 WP_126513442.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-63)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8735.22 Da        Isoelectric Point: 10.4776

>T287948 WP_005650834.1 NZ_LR134490:411864-412085 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELSPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 222 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT287948 WP_005650837.1 NZ_LR134490:412078-412374 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References