Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 338020..338624 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name relE Uniprot ID A0A0K9L7B7
Locus tag EL230_RS01690 Protein ID WP_005692344.1
Coordinates 338020..338328 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag EL230_RS01695 Protein ID WP_005692346.1
Coordinates 338328..338624 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS01680 333116..334414 - 1299 WP_126513418.1 trigger factor -
EL230_RS01685 334781..337963 + 3183 WP_164713684.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
EL230_RS01690 338020..338328 - 309 WP_005692344.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EL230_RS01695 338328..338624 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL230_RS01700 338745..338870 - 126 WP_005658455.1 selenocysteine synthase -
EL230_RS01705 338854..340713 - 1860 WP_126513419.1 selenocysteine-specific translation elongation factor -
EL230_RS01710 340710..342095 - 1386 WP_116939688.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11974.77 Da        Isoelectric Point: 8.4339

>T287945 WP_005692344.1 NZ_LR134490:c338328-338020 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCYIQGNLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT287945 WP_005692346.1 NZ_LR134490:c338624-338328 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L7B7

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References