Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46221..46852 Replicon chromosome
Accession NZ_LR134490
Organism Haemophilus influenzae strain NCTC11873

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL230_RS00230 Protein ID WP_005648013.1
Coordinates 46454..46852 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag EL230_RS00225 Protein ID WP_005648011.1
Coordinates 46221..46454 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL230_RS00200 41699..42901 - 1203 WP_126513381.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
EL230_RS00205 43065..43730 + 666 WP_020910156.1 DNA repair protein RadC -
EL230_RS00210 43944..44180 + 237 WP_005542826.1 50S ribosomal protein L28 -
EL230_RS00215 44192..44362 + 171 WP_005613503.1 50S ribosomal protein L33 -
EL230_RS00220 44710..46074 + 1365 WP_005648009.1 diaminobutyrate--2-oxoglutarate transaminase -
EL230_RS00225 46221..46454 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
EL230_RS00230 46454..46852 + 399 WP_005648013.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL230_RS00235 46872..48407 + 1536 WP_005648022.1 L-2,4-diaminobutyrate decarboxylase -
EL230_RS00240 48639..49454 + 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
EL230_RS00245 49526..50548 - 1023 WP_005648024.1 outer membrane-stress sensor serine endopeptidase DegS -
EL230_RS00250 50549..51667 - 1119 WP_075985380.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15073.38 Da        Isoelectric Point: 8.0514

>T287944 WP_005648013.1 NZ_LR134490:46454-46852 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAGIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT287944 WP_005648011.1 NZ_LR134490:46221-46454 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References