287938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3649432..3650051 Replicon chromosome
Accession NZ_LR134485
Organism Citrobacter youngae strain NCTC13709

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag EL296_RS18235 Protein ID WP_002892050.1
Coordinates 3649833..3650051 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag EL296_RS18230 Protein ID WP_003021733.1
Coordinates 3649432..3649806 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL296_RS18220 3644578..3645771 + 1194 WP_048212410.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL296_RS18225 3645794..3648943 + 3150 WP_048212411.1 efflux RND transporter permease AcrB -
EL296_RS18230 3649432..3649806 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
EL296_RS18235 3649833..3650051 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
EL296_RS18240 3650260..3650790 + 531 WP_126320197.1 maltose O-acetyltransferase -
EL296_RS18245 3650907..3651377 + 471 WP_040232692.1 YlaC family protein -
EL296_RS18250 3651455..3651595 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
EL296_RS18255 3651597..3651857 - 261 WP_124021513.1 type B 50S ribosomal protein L31 -
EL296_RS18260 3652046..3653599 + 1554 WP_048212413.1 EAL domain-containing protein -
EL296_RS18265 3653654..3654007 - 354 WP_061067436.1 DUF1428 family protein -
EL296_RS18270 3654090..3654701 - 612 WP_061067435.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287938 WP_002892050.1 NZ_LR134485:3649833-3650051 [Citrobacter youngae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT287938 WP_003021733.1 NZ_LR134485:3649432-3649806 [Citrobacter youngae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References